Monday, March 30, 2009

Forum URL Change

Recently Proboards (the people who host the forum) have upgraded the forum's url by taking out the number

So instead of the old url with the number in it -

It is now so if you have the forum bookmarked or are linked to it from your website/blog it would be best to upgrade it. The old url should redirect you to the new one but it's best to update it just in case.


Saturday, March 28, 2009

Neuropsychological Performance in Persons With ME

Neuropsychological Performance in Persons With Chronic Fatigue Syndrome: Results From a Population-Based Study

Objective: To examine the neuropsychological function characterised in subjects with chronic fatigue syndrome (CFS) at the same time controlling for relevant confounding factors. CFS is associated with symptoms of neuropsychological dysfunction. Objective measures of neuropsychological performance have yielded inconsistent results possibly due to sample selection bias, diagnostic heterogeneity, co-morbid psychiatric disorders, and medication usage.

Method: CFS subjects (n = 58) and well controls (n = 104) from a population-based sample were evaluated, using standardised symptom severity criteria. Subjects who had major psychiatric disorders or took medications known to influence cognition were excluded. Neuropsychological function was measured using the Cambridge Neuropsychological Test Automated Battery (CANTAB).

Results: Compared with controls, CFS subjects exhibited significant decreases in motor speed as measured in the simple and five-choice movement segments of the CANTAB reaction time
task. CFS subjects also exhibited alterations in working memory as manifested by a less efficient search strategy on the spatial working memory task, fewer % correct responses on the spatial recognition task, and prolonged latency to a correct response on the pattern recognition task. A significantly higher percentage of CFS subjects versus controls exhibited evidence of neuropsychological impairment (defined by performance 1 standard deviation below the CANTAB normative mean) in tasks of motor speed and spatial working memory. Impairment in CFS subjects versus control subjects ranged from 20% versus 4.8% in five-choice movement time (p = .002) to 27.8% versus 10.6% in search strategy on the spatial working memory task (p = .006).

Conclusions: These results confirm and quantify alterations in motor speed and working memory in CFS subjects independent of co-morbid psychiatric disease and medication usage.

For a more in depth read of the research click here (PDF)
Source -

Monday, March 23, 2009

Lower Ambulatory Blood Pressure in ME/CFS

Journal: Psychosom Med. 2009 Mar 17. [Epub ahead of print]
Authors: Newton JL, Sheth A, Shin J, Pairman J, Wilton K, Burt JA, Jones DE.
Affiliation: Institute for Cellular Medicine, University of
Newcastle, Newcastle-upon-Tyne, United Kingdom.
NLM Citation: PMID: 19297309

Objective: To examine blood pressure circadian rhythm in subjects with chronic fatigue syndrome (CFS) and appropriate normal and fatigued controls to correlate parameters of blood pressure regulation with perception of fatigue in an observational cohort study. The cause of CFS remains unknown and there are no effective treatments.

Methods: To address whether inactivity was a confounder, we performed a 24-hour ambulatory blood pressure monitoring in the following three subject groups: 1) CFS patients (Fukuda Diagnostic criteria) (n = 38); 2) normal controls (n = 120); and 3) a fatigue comparison group (n = 47) with the autoimmune liver disease primary biliary cirrhosis (PBC). All patients completed a measure of fatigue severity (Fatigue Impact Scale). In view of the different demographics between the patient groups, patients were age- and sex-matched on a case-by-case basis to normal controls and blood pressure parameters were compared.

Results: Compared with the control population, the CFS group had significantly lower systolic blood pressure (p < .0001) and mean arterial blood pressure (p = .0002) and exaggerated diurnal variation (p = .009). There was a significant inverse relationship between increasing fatigue and diurnal variation of blood pressure in both the CFS and PBC groups (p < .05). Conclusion: Lower blood pressure and abnormal diurnal blood pressure regulation occur in patients with CFS. We would suggest the need for a randomized, placebo-controlled trial of agents to increase blood pressure such as midodrine in CFS patients with an autonomic phenotype.

Posted @ Forum by Upnorth