Wednesday, January 14, 2009

Co-enzyme Q10 distribution in blood is altered in patients with Fibromyalgia


OBJECTIVE: Co-enzyme Q10 (CoQ(10)) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs and symptoms associated with muscular alteration and mitochondrial dysfunction, including oxidative stress, have been observed in patients with fibromyalgia (FM). The aim was to study CoQ(10) levels in plasma and mono nuclear cells, and oxidative stress in FM patients.

METHODS: We studied CoQ(10) levels by HPLC in plasma and peripheral mono nuclear cells obtained from patients with FM and healthy control subjects. Oxidative stress markers were analysed in both plasma and mono nuclear cells from FM patients.

RESULTS: Higher level of oxidative stress markers in plasma was observed respect to control subjects. CoQ(10) level in plasma samples from FM patients was doubled compared to healthy controls and in blood mononucleosis isolated from 37 FM patients was found to be about 40% lower. Higher levels of ROS production was observed in mono nuclear cells from FM patients compared to control, and a significant decrease was induced by the presence of CoQ(10).

CONCLUSION: The distribution of CoQ(10) in blood components was altered in FM patients. Also, our results confirm the oxidative stress background of this disease probably due to a defect on the distribution and metabolism of CoQ(10) in cells and tissues. The protection caused inmononuclear cells by CoQ(10) would indicate the benefit of its supplementation in FM patients.

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